The attachment of specific chemical groups to individual RNAs introduces novel chemical properties and strongly influences their functionality. Individual ribosomes, mRNAs and tRNAs are dynamically modified depending on cell type and compartment, metabolic state and environmental conditions. This complexity creates specialised translational units and expands the regulatory potential of the core translation machinery. The EU-funded tRNAslation project aims to characterise key RNA modification complexes and understand the role of individual rRNA and tRNA modifications during translation elongation by creating sets of fully modified RNAs in vitro. Ultimately, this might provide mechanistic insight into links between mutations found in patients, the underlying pathways and the onset of severe illnesses.
This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 101001394).
EU contribution: 1 997 500 EUR
Programme: H2020-EU.1.1. – EXCELLENT SCIENCE – European Research Council (ERC)
Funding call: ERC-2020-COG – ERC CONSOLIDATOR GRANTS
Funding period: 1st June 2021 – 1st June 2026
tRNAslation project on the EU CORDIS platform: https://cordis.europa.eu/project/id/101001394
Funding agency – ERC: https://erc.europa.eu/