Half Way to Hypusine - new paper from our users

April 9th, 2020

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Needless to say, how important posttranslational modifications (PTMs) are for protein function but among hundreds of known PTMs, one is particularly rare and interesting, namely the hypusine

Hypusination is a process of lysine side chain elongation and is found uniquely in eIF5A – a translation factor involved in the proper protein production and cell survival. This modification to occur requires an orchestrated action of two enzymes and our team investigated structural aspects of Deoxyhypusine Synthase (DHS) which is catalyzing the first step of hypusination. The study by Wątor et al presents a series of high-resolution crystal structures determined with the help of the state of the art MX beamlines at BESSY II. Our results lay a foundation for the future efforts aiming at the development of a set of chemical compounds allowing to modulate the activity of DHS. Such tools may help to fight cancer or neurodegenerative diseases. The research has been funded by the National Science Center Opus grant to Dr. Przemysław Grudnik and was conducted using the resources of Structural Biology Core Facility at MCB.

Results were published recently in the Biomolecules Special Issue: Biogenic Polyamines and Related Metabolites.

hypusination
photo by Ela Wątor